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  • Title: Membrane protein insertion into the endoplasmic reticulum--another channel tunnel?
    Author: High S.
    Journal: Bioessays; 1992 Aug; 14(8):535-40. PubMed ID: 1365907.
    Abstract:
    The synthesis of biological membranes requires the insertion of proteins into a lipid bilayer. The rough endoplasmic reticulum of eukaryotic cells is a principal site of membrane biogenesis. The insertion of proteins into the membrane of the endoplasmic reticulum is mediated by a resident proteinaceous machinery. Over the last five years several different experimental approaches have provided information about the components of the machinery and how it may function.
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