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  • Title: Assay of suxamethonium and laudexium on the frog rectus abdominis.
    Author: BRITTAIN RT, CHESHER BG, COLLIER HO, GRIMSHAW JJ.
    Journal: Br J Pharmacol Chemother; 1959 Jun; 14(2):158-63. PubMed ID: 13662566.
    Abstract:
    Suxamethonium, like acetylcholine, causes contracture of the isolated rectus abdominis muscle of the frog, whereas laudexium antagonizes this effect. These actions may be used to assay both drugs with reasonable speed and fiducial limits, provided that changes in responsiveness of the preparation during the course of assay are met by suitable design and analysis. Small quantities of suxamethonium and laudexium may be assayed in certain body fluids.
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