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  • Title: [Relation of epithelial metaplasia and calcification with epithelial proliferation in fibrocytic breast disease].
    Author: Savjak D, Pikula B.
    Journal: Med Arh; 1991; 45(1-2):59-62. PubMed ID: 1366322.
    Abstract:
    By semiserial microscopic investigation of the complete tissue of 65 surgical excised fibrocystic lesion of female breast we have found that there exist (a) the high frequency (58.5%) of the apocrine metaplastic epithelium, predominantly located in lobules and topographically widely distributed (mean 9 focuses on a sample), (b) the rare occurrence (3%) of lobular and ductal squamous metaplasia and (c) the high frequency (40%) of sparse (mean 3 focuses on a sample) lobular calcifications. Statistically, apocrine metaplasia and calcifications were significantly (p < 0.001 and p < 0.01) more frequent in the samples of proliferative fibrocystic lesions. The level of the positive spacial correlation (O = 0.512) of proliferative and apocrine metaplastic epithelial changes, as well as a common stratification and papillation of the apocrine epithelium indicate indirectly a possible influence of a steroid hormonal unbalance in the promotion of the apocrine epithelial metaplasia.
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