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  • Title: Modular integrated fluidized bed bioreactor technology.
    Author: Reiter M, Blüml G, Gaida T, Zach N, Unterluggauer F, Doblhoff-Dier O, Noe M, Plail R, Huss S, Katinger H.
    Journal: Biotechnology (N Y); 1991 Nov; 9(11):1100-2. PubMed ID: 1367626.
    Abstract:
    We describe the design and demonstrate the application of a modular integrated fluidized bed bioreactor system. Basically the system is a reactor vessel equipped with an extending cylinder and a liquid distributor plate. Instead of an external recirculation loop, as used in existing fluidized bed systems, a low shear stress impeller is used as the recirculation pump. The system has several unique features, such as modular exchangeable elements, efficient oxygenation and the option of operating as a stirred tank-, a packed bed- or a fluidized bed reactor. An example of a fluidized bed run using CHO-K1 cells is shown. Under standard culture conditions a 100-fold increase in cell density (up to 1.2 x 10(8) cells/ml) was achieved.
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