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  • Title: Effect of cacao husk extract on human immunodeficiency virus infection.
    Author: Unten S, Ushijima H, Shimizu H, Tsuchie H, Kitamura T, Moritome N, Sakagami H.
    Journal: Lett Appl Microbiol; 1991 Dec; 13(6):251-4. PubMed ID: 1367748.
    Abstract:
    A sodium hydroxide extract from cacao husk inhibited the cytopathic effect of human immunodeficiency virus type 1 (HIV-1) against HTLV-1-transformed T-cell lines MT-2 and MT-4. It also inhibited syncytium formation between HIV-infected and uninfected lymphoblastoid T-cell line, MOLT-4. The anti-HIV activity was concentrated by membrane filter fractionation to a fraction with molecular weight of 100-300 KDa. Anti-HIV activity of the extract was attributable to interference with the virus adsorption, rather than to inhibition of the virus replication after adsorption.
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