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  • Title: A model synapse that incorporates the properties of short- and long-term synaptic plasticity.
    Author: Sargsyan AR, Melkonyan AA, Papatheodoropoulos C, Mkrtchian HH, Kostopoulos GK.
    Journal: Neural Netw; 2003 Oct; 16(8):1161-77. PubMed ID: 13678620.
    Abstract:
    We propose a general computer model of a synapse, which incorporates mechanisms responsible for the realization of both short- and long-term synaptic plasticity-the two forms of experimentally observed plasticity that seem to be very significant for the performance of neuronal networks. The model consists of a presynaptic part based on the earlier 'double barrier synapse' model, and a postsynaptic compartment which is connected to the presynaptic terminal via a feedback, the sign and magnitude of which depend on postsynaptic Ca(2+) concentration. The feedback increases or decreases the amount of neurotransmitter which is in a ready for release state. The model adequately reproduced the phenomena of short- and long-term plasticity observed experimentally in hippocampal slices for CA3-CA1 synapses. The proposed model may be used in the investigation of certain real synapses to estimate their physiological parameters, and in the construction of realistic neuronal networks.
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