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  • Title: Studies on the blood lipids and lipoproteins in thalassaemia and sickle cell anaemia.
    Author: CHOREMIS C, KYRIAKIDES V, PAPADAKIS E.
    Journal: J Clin Pathol; 1961 Jul; 14(4):361-4. PubMed ID: 13693281.
    Abstract:
    In Cooley's anaemia the serum lipid fraction, determined by chemical analysis, was found to be decreased. The lipoprotein distribution by paper electrophoresis showed a characteristic pattern with abnormally low alpha(1) fraction and high concentrations of the beta fractions. There is no relationship between age and serum lipoprotein distribution. A correlation was found between the electrophoretic pattern, liver function tests, and the E/C index. Similar changes but of lesser degree were found in sickle cell anaemia. Liver damage is thought to be the probable cause of the reduced alpha(1) fraction.
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