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  • Title: Studies on infection and immunity in experimental typhoid fever. III. Effect of prophylactic immunization.
    Author: GAINES S, LANDY M, EDSALL G, MANDEL AD, TRAPANI RJ, BENENSON AS.
    Journal: J Exp Med; 1961 Sep 01; 114(3):327-42. PubMed ID: 13702952.
    Abstract:
    A study was made of the efficacy of various antityphoid immunizing agents in immunizing chimpanzees against typhoid fever produced by feeding viable S. typhosa. It was found that both acetone-killed and heat-killed, phenol-preserved typhoid vaccines were effective in protecting against infection induced with either homologous or heterologous strains of typhoid bacilli. Purified O antigen induced no discernible protection, but some immunity was afforded by the administration of purified Vi antigen.
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