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  • Title: Bar to normal UGA translation by the selenocysteine tRNA.
    Author: Li WQ, Yarus M.
    Journal: J Mol Biol; 1992 Jan 05; 223(1):9-15. PubMed ID: 1370545.
    Abstract:
    The selC gene product, tRNA(Sec), inserts selenocysteine at UGA (opal) codons in a specialized mRNA context. We have investigated the action of the tRNA at ordinary UGA codons, normally not translated, by changing the unusual structural features of tRNA(Sec). Sequences in the D arm, CCA arm and variable arm of the tRNA all contribute to the prohibition against translation of ordinary UGA codons. One multiple mutant is a moderately efficient serine-inserting UGA suppressor tRNA.
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