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  • Title: Thioguanine-resistant mutant frequency in T-lymphocytes from a healthy human population.
    Author: Davies MJ, Lovell DP, Anderson D.
    Journal: Mutat Res; 1992 Feb; 265(2):165-71. PubMed ID: 1370715.
    Abstract:
    Resistance to 6-thioguanine in T-lymphocytes was used to study in vivo somatic mutations in normal healthy adults. Donor age had a significant effect on mutant frequency at the hprt locus, showing an increase of 0.09/10(6) cells per year of age. No significant increase was associated with sex of donor, smoking habits, alcohol or coffee/tea intake, or X-ray exposure. The lower mutant frequency seen with contraceptive pill usage was probably due to the age difference between the groups of users and non-users.
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