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  • Title: Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system.
    Author: Rubiolo P, Pieters L, Calomme M, Bicchi C, Vlietinck A, Vanden Berghe D.
    Journal: Mutat Res; 1992 Feb; 281(2):143-7. PubMed ID: 1370983.
    Abstract:
    The mutagenicity of a series of pyrrolizidine alkaloids, and of extracts from several Italian Senecio species containing pyrrolizidine alkaloids, including S. inaequidens, S. fuchsii and S. cacaliaster, were tested using the Salmonella typhimurium/mammalian microsome system. Retrorsine, senecivernine, seneciphylline and the Senecio extracts showed a weakly mutagenic activity.
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