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  • Title: Preservation of endothelium-dependent vasodilation in the spastic segment of the human epicardial coronary artery by substance P.
    Author: Yamamoto H, Yoshimura H, Noma M, Kai H, Suzuki S, Tajimi T, Sugihara M, Kikuchi Y.
    Journal: Am Heart J; 1992 Feb; 123(2):298-303. PubMed ID: 1371034.
    Abstract:
    The objective of this study was to determine if endothelium-dependent vasodilation is preserved in the spastic segment of the epicardial coronary artery. Segmental responses of the coronary artery to substance P were examined by the use of a quantitative angiographic technique in 21 patients with variant angina. Coronary diameter at the basal state did not differ between the spastic and the nonspastic segments (2.3 +/- 0.2 mm, 2.3 +/- 0.4 mm, p greater than 0.05). Changes in coronary diameter in response to substance P did not differ between segments with ergonovine-induced spasm and nonspastic segments. Maximal dilation averaged 27.1 +/- 9.5% in the spastic segment and 24.4 +/- 9.6% in the nonspastic segment (expressed as a percent increase over the value before drug administration). It appears that both the potential of the endothelium to release endothelium-dependent relaxing factor and the dilating response of the smooth muscle to endothelium-dependent relaxing factor are preserved, even in the spastic segment.
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