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  • Title: Endopeptidase 24.15 modulates bradykinin-induced contraction in guinea-pig trachea.
    Author: Da Silva A, Dhuy J, Waeldelé F, Bertrand C, Landry Y.
    Journal: Eur J Pharmacol; 1992 Feb 25; 212(1):97-9. PubMed ID: 1372868.
    Abstract:
    Guinea-pig tracheal strips were contracted with cumulative concentrations of bradykinin or substance P in the presence of thiorphan, an inhibitor of endopeptidase 24.11 and of angiotensin-converting enzyme, or in the presence of N-[1-(R,S)-carboxy-3-phenylpropyl]Ala-Ala-Phe-para-aminobenzoate (cFP-AAF-pAB), a selective inhibitor of endopeptidase 24.15. The concentration-effect curve of bradykinin was shifted to the left in the presence of each inhibitor whereas the curve of substance P was sensitive to thiorphan but not to cFP-AAF-pAB. These results show that endopeptidase 24.15 may modulate the contractile effect of bradykinin but not that of substance P in the guinea-pig trachea.
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