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  • Title: Rupture of ectopic pregnancy following disappearance of serum beta subunit of hCG.
    Author: Hochner-Celnikier D, Ron M, Goshen R, Zacut D, Amir G, Yagel S.
    Journal: Obstet Gynecol; 1992 May; 79(5 ( Pt 2)):826-7. PubMed ID: 1373479.
    Abstract:
    The introduction of sensitive assays for the beta subunit of hCG (beta-hCG) and improved ultrasound technology for diagnosis and monitoring of ectopic pregnancy have changed the clinical approach to the management of ectopic pregnancy. Only a few reports have been published of patients with ectopic gestation and negative serum beta-hCG levels. None of these described rupture of ectopic pregnancy following the decline of beta-hCG levels to below 10 mIU/mL. We describe a case of ectopic pregnancy, managed expectantly, in which rupture and hemoperitoneum occurred after the decline of beta-hCG levels to below 10 mIU/mL.
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