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  • Title: Evidence for a fourth rat isoform of the plasma membrane calcium pump in the kidney.
    Author: Gonzalez JM, Dalmeida W, Abramowitz J, Suki WN.
    Journal: Biochem Biophys Res Commun; 1992 Apr 15; 184(1):387-93. PubMed ID: 1373614.
    Abstract:
    This study was conducted to identify plasma membrane Ca(2+)-transporting ATPases present in rat kidney. Characterization of the cDNAs of the plasma membrane Ca(2+)-ATPases revealed a family of proteins with regions of highly conserved amino acid sequence. To examine the extent of the diversity of rat renal plasma membrane Ca(2+)-ATPases, we used the polymerase chain reaction to detect additional gene products in rat kidney mRNA that shared these conserved regions. Sequences corresponding to three previously known rat plasma membrane Ca(2+)-ATPases were obtained. In addition, we found sequence corresponding to a new putative plasma membrane Ca(2+)-ATPase. Our results demonstrate that the rat kidney contains at least four different plasma membrane Ca(2+)-ATPases and the complexity of this multigene family is greater than previously thought.
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