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Title: Rat KC cDNA cloning and mRNA expression in lung macrophages and fibroblasts. Author: Huang S, Paulauskis JD, Kobzik L. Journal: Biochem Biophys Res Commun; 1992 Apr 30; 184(2):922-9. PubMed ID: 1374243. Abstract: We have isolated and sequenced overlapping cDNA clones for rat KC*. The 0.93 kb cDNA has a single open reading frame of 288 nucleotides, and substantial sequence identity with the platelet-factor 4 family members mouse KC, hamster gro, and human gro. Using cloned cDNA as a probe, expression of KC mRNA in lavaged rat alveolar macrophages (AMs) increased after lipopolysaccharide (LPS) treatment. We also studied expression in vitro by a rat fetal lung fibroblast cell line, RFL-6. Expression of KC mRNA in RFL-6 cells increased after treatment with interleukin 1 or with conditioned medium from rat AMs treated with LPS.[Abstract] [Full Text] [Related] [New Search]