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  • Title: Histochemistry of NADPH-diaphorase, a marker for neuronal nitric oxide synthase, in the peripheral autonomic nervous system of the mouse.
    Author: Grozdanovic Z, Baumgarten HG, Brüning G.
    Journal: Neuroscience; 1992; 48(1):225-35. PubMed ID: 1374863.
    Abstract:
    In order to identify possible sites of synthesis of nitric oxide in the peripheral nervous system, several mouse organs were investigated for the presence of NADPH-diaphorase activity. Diaphorase-positive neurons and fibers were localized in the tongue, submandibular salivary glands, gastrointestinal and biliary duct systems, lower urinary tract and pelvic ganglia. By thionin counterstaining it was found that a distinct subpopulation of neurons was labeled. The present study indicates that nitric oxide synthase may be present in intrinsic neurons of various organs, suggesting a widespread function of nitric oxide in the peripheral autonomic nervous system.
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