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  • Title: Comparative binding study of aluminum and chromium to human transferrin. Effect of iron.
    Author: Moshtaghie AA, Ani M, Bazrafshan MR.
    Journal: Biol Trace Elem Res; 1992; 32():39-46. PubMed ID: 1375080.
    Abstract:
    The characteristics of aluminum and chromium binding to apo-transferrin (apo-tf) have been investigated and compared. Both metal ions were taken up by human transferrin forming complexes with the maximum absorbances at 405 nm for chromium-transferrin (cr-tf) and 240 nm for aluminum-transferrin (Al-tf). In the presence of citric acid, chromium binding to transferrin is five times more than aluminum. The binding of aluminum or chromium to apo-transferrin was reduced by 18 and 22% in the presence of 200 ng/mL of iron. The binding of both metals to apo-tf appears to be pH dependent. In acidic pHs, less chromium and more aluminum binding occurred.
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