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  • Title: Characterization of the human IgG antibody VL repertoire to Haemophilus influenzae type b polysaccharide.
    Author: Scott MG, Nahm MH.
    Journal: J Infect Dis; 1992 Jun; 165 Suppl 1():S53-6. PubMed ID: 1375255.
    Abstract:
    The human antibody response to the capsular polysaccharide of Haemophilus influenzae type b (Hib) is a good model for examining human V region repertoires. While the VL repertoire of human antibodies to Hib polysaccharide is relatively simple and dominated by the product of a germline V kappa II gene named A2, at least five other VL genes can be expressed by some individuals. These include at least two V kappa I products and at least one V kappa III, one V kappa IV, and one V lambda product. The epitope recognized by a monoclonal anti-idiotype antibody is on the A2 V kappa II product.
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