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  • Title: The cGMP-gated channel of rod outer segments is not localized in bipolar cells of the mammalian retina.
    Author: Wässle H, Grünert U, Cook NJ, Molday RS.
    Journal: Neurosci Lett; 1992 Jan 06; 134(2):199-202. PubMed ID: 1375352.
    Abstract:
    It has recently been suggested (Nature, 346 (1990) 269-271) that ON-bipolar cells express the same biochemical cascade and guanosine 3',5'-cyclic monophosphate (cGMP)-gated cation channel as rod outer segments. An antibody directed against the cGMP-gated channel of bovine rod outer segments was applied to cryostat sections of rat and cat retinae. No immunocytochemical labelling was found in bipolar cells. Therefore, if those cells express a cGMP-gated channel, it must be immunologically different to the 63 kDa protein constituting the cGMP-gated channel of the outer segment.
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