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  • Title: Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter.
    Author: Armstrong E, Partanen J, Cannizzaro L, Huebner K, Alitalo K.
    Journal: Genes Chromosomes Cancer; 1992 Jan; 4(1):94-8. PubMed ID: 1377018.
    Abstract:
    Our polymerase chain reaction cloning of novel tyrosine kinases expressed in the K562 chronic myeloid leukemia cells has revealed a novel fibroblast growth factor receptor, FGFR4. We have here mapped the FGFR4 gene by analysis of somatic cell hybrids and in situ hybridization to the 5q33-qter chromosomal region. This finding is of interest in that the FGFR4 gene is expressed in several leukemia cell lines and the 5q33-qter region is involved in nonrandom chromosomal translocations in acute myelogenous leukemias and Ki-I lymphomas.
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