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  • Title: Treatment of myelodysplastic syndromes with hematopoietic growth factors.
    Author: Ganser A, Hoelzer D.
    Journal: Hematol Oncol Clin North Am; 1992 Jun; 6(3):633-53. PubMed ID: 1377194.
    Abstract:
    Clinical trials with hematopoietic growth factors (granulocyte-macrophage colony-stimulating factor [GM-CSF], granulocyte colony-stimulating factor [G-CSF], interleukin-3, or erythropoietin) have been performed on patients with myelodysplastic syndromes. Absolute neutrophil counts can be readily raised to within the normal range by treatment with GM-CSF or G-CSF. Increases in platelets and hemoglobin have been reported after treatment with interleukin-3 and erythropoietin, respectively. Cytogenetic and molecular genetic analyses have demonstrated that both normal and malignant precursor cells are stimulated by cytokine therapy.
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