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  • Title: RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme.
    Author: Pyle AM, Murphy FL, Cech TR.
    Journal: Nature; 1992 Jul 09; 358(6382):123-8. PubMed ID: 1377367.
    Abstract:
    In catalysis by group I introns, the helix (P1) containing the RNA cleavage site must be positioned next to the guanosine binding site. We have identified a conserved adenine in the catalytic core that contributes to the stability of this arrangement and propose that it accepts a hydrogen bond from a specific 2'-OH in P1. Such base-backbone tertiary interactions may be generally important to the organization of RNA tertiary structure.
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