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  • Title: Immune surveillance against Epstein-Barr virus.
    Author: Moss DJ, Burrows SR, Khanna R, Misko IS, Sculley TB.
    Journal: Semin Immunol; 1992 Apr; 4(2):97-104. PubMed ID: 1377517.
    Abstract:
    Following primary infection, EBV retains a life-long latent association with B lymphocytes and a permissive association with stratified epithelium in the oropharynx. This review presents a model for the host-virus relationships in healthy virus carriers, a relationship which, if perturbed, may result in EBV-associated disease. Cytotoxic T cells that recognise virally-determined epitopes on infected cells are the major effector arm and control the persistant infection. A strategy for developing a vaccine to EBV is discussed.
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