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  • Title: Improvement in experimental vascular graft patency by controlled defibrinogenation.
    Author: Postlethwaite JC, Goyle KB, Dormandy JA, Hynd JW.
    Journal: Br J Surg; 1977 Jan; 64(1):28-30. PubMed ID: 137762.
    Abstract:
    A sensitive animal model was used to investigate treatment designed to improve vascular graft patency. A Dacron graft was inserted into the infrarenal vena cava of 30 rabbits. Half were treated with subcutaneous Arvin for 28 days after operation. This produced a significant lowering of the post operative plasma fibrinogen. The patency rate of the grafts in the treated rabbits was significantly greater than in the control rabbits.
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