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  • Title: A comparison of carvedilol with a combination of propranolol and isosorbide dinitrate in the chronic treatment of stable angina.
    Author: Nahrendorf W, Rading A, Steinig G, van der Does R, Schlote A.
    Journal: J Cardiovasc Pharmacol; 1992; 19 Suppl 1():S114-6. PubMed ID: 1378136.
    Abstract:
    The beta-blocking and vasodilating agent carvedilol was compared with a combination of propranolol and isosorbide dinitrate (ISDN) in a double-blind, parallel-group study. After two baseline sitting bicycle exercise tests on placebo, 31 patients with chronic stable angina were asymmetrically randomized to treatment with carvedilol (25 mg b.i.d.) or propranolol-ISDN (80 mg/20 mg b.i.d.) for a period of 6 months. Further exercise tests were performed 2 h after the first dose as well as after 1, 3, and 6 months of treatment. Twenty-seven patients were considered evaluable for efficacy. Differences between the two groups were observed with emphasis on total exercise time and time to 1-mm ST-segment depression. In contrast to a greater peak effect of the first propranolol/ISDN dose, the chronic antianginal and anti-ischemic effects of carvedilol at trough were found to be more marked than those of the combination.
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