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  • Title: [Mechanical activity of the papillary muscles of the rat heart under high altitude conditions].
    Author: Daniiarov SB, Karasaeva AKh, Naumova TN.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1976; 62(6):906-11. PubMed ID: 137822.
    Abstract:
    Mechanical activity of isolated papillary muscles in the left ventricle of rats was studied during permanent high altitude adaptation. The main computer parameters were: maximal developing tension, force of contraction, and capacity of papillary muscles at different periods of mountain adaptation (3, 15, 30 and 45 days). On the 15th day of mountain exposure, a statistically significant increase of maximal developing tension and papillary muscles activity was observed, which remained until the 45th day. Capacity was considerably increased on the 30th--45th day of adaptation. The data suggest positive effect of high altitude hypoxia on inotropic function of intact myocardium.
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