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  • Title: Increase in endogenous fibrinolysis and platelet activity during exercise in young volunteers.
    Author: Beisiegel B, Treese N, Hafner G, Meyer J, Darius H.
    Journal: Agents Actions Suppl; 1992; 37():183-9. PubMed ID: 1378684.
    Abstract:
    The influence of physical exercise and intake of oral contraceptives on endogenous fibrinolytic activity and platelet aggregation behaviour was studied in young healthy women and compared to an age matched group of male volunteers. Physical exercise beyond the anaerobic threshold significantly increased the activity of tissue-plasminogen activator (t-PA) in male and female volunteers from initial values of 1.6 +/- 0.1 and 1.8 +/- 0.2 IU/ml to 5.5 +/- 1.0 and 5.3 +/- 0.9 IU/ml (P less than 0.01), respectively. In women taking low-dose estrogen oral contraceptives t-PA increased from 1.5 +/- 0.2 to 3.8 +/- 0.5 (P less than 0.01). There were no major alterations in plasminogen activator inhibitor - I (PAI-I) plasma activities. Platelet activity during exercise was significantly enhanced in male test persons indicated by a significant decrease in the ED50 values for ADP. In contrast, in women ED50 values were basically unaltered, irrespective of the intake of oral contraceptives. Physicians at the Medical Clinic at the Johannes Gutenberg University in Mainz, Germany, compared data on 6 18-35 year old healthy women who took low-dose estrogen oral contraceptives (OCs) with data on 10 healthy women of same age who did not take OCs and with data on 12 18-35 year old males to examine gender differences of the coagulation system, endogenous fibrinolytic activity, and platelet aggregation under normal conditions and immediately after spiroergometric exercise beyond the anaerobic threshold. This type of exercise considerably boosted tissue plasminogen activator (t-PA) in both men and women (1.6-5.5 IU/ml and 1.8-5.3 IU/ml, respectively; p .005). The increase was not as high in women using the low-dose estrogen OCs as it was for men and both groups combined, however; but the increase was still significant (1.5-3.8 IU/ml; p .005). Plasma lactate levels were 1.1 mmol/l in men and 0.5 mmol/l in both female groups and rose significantly in all 3 groups (about 5.5 mmol/l for men and about 2.5 mmol/l for women; p .001). Exercise beyond the anaerobic threshold did not change plasminogen activator inhibitor-I activities. A marked fall in the ED50 values for adenosine diphosphate (ADP) in men indicated considerable enhancement of platelet activity during exercise (p .05). ADP ED50 values did not change significantly in either women's groups. Yet women who took the OCs had a lower ED50 for ADP than both men and women not taking the OCs, suggesting they were more susceptible to platelet aggregation under control conditions and after exercise. These findings indicated a considerable gender difference in platelet aggregation and activation of the endogenous fibrinolytic system both at rest and during exercise. It was also pointed out that women taking OCs are at even greater risk of developing thrombosis than women not taking OCs.
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