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  • Title: Why do tumor cells have a high aerobic glycolysis?
    Author: Racker E.
    Journal: J Cell Physiol; 1976 Dec; 89(4):697-700. PubMed ID: 137907.
    Abstract:
    In Ehrlich ascites cells and several other tumors, the high aerobic glycolysis is maintained by generation of ADP and Pi by the plasma membrane Na+K+ ATPase. The high ATP activity is caused by a defective pump that operates at a low efficiency. Studies of the mechanism of action of the Na+K+ ATPase and other pump ATPases suggest several alternative mechanisms that might account for the decreased efficiency. The possibility of involvement of a proteolipid is under investigation.
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