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  • Title: Enzymatic O-methylation of N-acetylserotonin to melatonin.
    Author: AXELROD J, WEISSBACH H.
    Journal: Science; 1960 Apr 29; 131(3409):1312. PubMed ID: 13795316.
    Abstract:
    An enzyme, hydroxyindole-O-methyl transferase, that can transfer the methyl group of S-adenosylmethionine to the hydroxy group of N-acetylserotonin to form the hormone melatonin is described. This enzyme, which is highly localized in the pineal gland, also O-methylates serotonin.
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