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  • Title: [Prevention of post-transfusion non-A, non-B hepatitis by anti-HCV screening].
    Author: Holzberger G, Seidl S, Peschke B, Scheuermann EH, Schoeppe W.
    Journal: Infusionsther Transfusionsmed; 1992 Jun; 19(3):157-9. PubMed ID: 1379861.
    Abstract:
    Since May 1990 a specific enzyme immunoassay (EIA) for NANBH has been developed by recombinant DNA technology which detects antibodies to a virus called hepatitis C virus (HCV). The anti-HCV EIA was manufactured by Ortho-Diagnostic Systems with recombinant antigens from Chiron Corp. based on extraction from high infectious titre chimpanzee plasma RNA after transcription into cDNA. We tested the anti-HCV prevalence of blood donors and hemodialysis patients. The anti-HCV prevalence with the first generation test was 0.52% (Ortho), 0.87% (Abbott) in blood donors and 4.16% in hemodialysis patients. The second generation anti-HCV test (Abbott) with improved sensitivity and specificity comprises 0.25% repeated anti-HCV positive blood donors and 8.2% anti-HCV positive hemodialysis patients.
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