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  • Title: Recombinant human granulocyte colony-stimulating factor promotes wound healing in a patient with congenital neutropenia.
    Author: Besner GE, Glick PL, Karp MP, Wang WC, Lobe TE, White CR, Cooney DR.
    Journal: J Pediatr Surg; 1992 Mar; 27(3):288-90; discussion 291. PubMed ID: 1380074.
    Abstract:
    We report a patient with congenital neutropenia or Kostmann's Syndrome who suffered many complications after presenting with Clostridium septicum enterocolitis, including absence of wound healing. Because of several reports of the use of granulocyte colony-stimulating factor (G-CSF) in patients with various complications of neutropenia, we treated this patient with recombinant human (rh) G-CSF. We found that once rhG-CSF restored neutrophil counts to normal, progressive wound healing followed. Thus, rhG-CSF therapy may be useful in treating neutropenic patients with wound complications.
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