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  • Title: Alloimmune thrombocytopenia: in utero treatment by high doses of intravenous gamma globulins.
    Author: Poulain P, Kaplan C, Leberre C, Milon J, Bergeron C, Grall JY.
    Journal: Fetal Diagn Ther; 1992; 7(2):144-6. PubMed ID: 1380248.
    Abstract:
    The authors report successful in utero treatment by high doses of intravenous gamma globulins in a case of neonatal alloimmune thrombocytopenia. Early diagnosis allows an appropriate management: fetal blood sampling as early as 20 weeks of gestation; in case of fetal thrombocytopenia, treatment by intravenous gamma globulin (1.0 g/kg/b.w.) each week during 8 weeks or more; ultrasound screening of in utero hemorrhage, particularly intracranial hemorrhage; fetal blood sampling before delivery at term and in utero transfusion of platelet antigen negative in case of persistence of fetal thrombocytopenia.
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