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  • Title: Beta/A4 deposits and their relationship to senile plaques in Alzheimer's disease.
    Author: Armstrong RA, Myers D.
    Journal: Neuroreport; 1992 Mar; 3(3):262-4. PubMed ID: 1381229.
    Abstract:
    The density and spatial pattern of immunostained beta/A4 deposits and mature senile plaques (SP) stained by the Glees method were compared in Alzheimer's diseased brain. Thirty-seven percent of the variance in Glees SP density in a tissue could be explained by beta/A4. Both lesions were clustered with the beta/A4 clusters often larger than the Glees SP clusters. Beta/A4 and Glees SP cluster size were not correlated in a tissue. The size of Glees SP clusters was positively correlated with SP density but no correlation could be detected for beta/A4. Hence, the density and spatial pattern of beta/A4 deposits in most tissues did not predict the development of Glees SP.
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