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  • Title: CD7 expression in malignant pleural mesothelioma.
    Author: Hibi S, Kataoka Y, Fujita N, Okabe H, Yoshikawa K, Seto M, Ueda R, Imashuku S.
    Journal: Jpn J Cancer Res; 1992 Jul; 83(7):680-3. PubMed ID: 1381341.
    Abstract:
    CD7 antigen was found to be expressed on malignant mesothelioma arising from the right pleura in a 15-year-old girl not only by immunostaining using monoclonal antibodies, but also by Northern blot analysis. The level of expression in this tumor was comparable to those in T-cell lines, Jurkat and CCRF-CEM. Cytogenetic analysis of the tumor showed hypodiploidy (n = 43). CD7 has been regarded as one of the hematopoietic cell markers selectively expressed on the majority of T cells and multipotential stem cells. To our knowledge, this is the first report of a non-hematopoietic tumor expressing CD7.
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