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  • Title: Effects of substance P on extracellular dopamine in neostriatum and nucleus accumbens.
    Author: Boix F, Mattioli R, Adams F, Huston JP, Schwarting RK.
    Journal: Eur J Pharmacol; 1992 May 27; 216(1):103-7. PubMed ID: 1382019.
    Abstract:
    Microdialysis was used to monitor changes in dopamine release in the neostriatum and nucleus accumbens after peripheral administration of substance P in freely moving rats. Substance P in a dose of 50 micrograms/kg produced a steady moderate increase in dopamine levels in the neostriatum, which persisted for at least 5 h. In contrast, a dose of 250 micrograms/kg caused an acute increase in dopamine levels in the nucleus accumbens, which lasted about 2 h. These data suggest that the peripheral administration of substance P can influence dopamine release in mesolimbic and mesostriatal terminals.
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