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  • Title: K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea.
    Author: Kuo HP, Rohde JA, Barnes PJ, Rogers DF.
    Journal: Eur J Pharmacol; 1992 May 14; 215(2-3):297-9. PubMed ID: 1382999.
    Abstract:
    A potassium (K+) channel activator, BRL 38227, inhibited goblet cell secretion in guinea-pig trachea induced by either electrical stimulation of the vagus nerves or acute inhalation of cigarette smoke, two stimuli which activate both cholinergic nerves and capsaicin-sensitive sensory nerves. BRL 38227 failed to inhibit methacholine- or substance P-induced goblet cell secretion which suggests that K+ channel activators inhibit neurogenic goblet cell secretion via a prejunctional effect on cholinergic and sensory nerves.
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