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  • Title: Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic.
    Author: Galzi JL, Devillers-Thiéry A, Hussy N, Bertrand S, Changeux JP, Bertrand D.
    Journal: Nature; 1992 Oct 08; 359(6395):500-5. PubMed ID: 1383829.
    Abstract:
    Introduction by site-directed mutagenesis of three amino acids from the MII segment of glycine or gamma-aminobutyric acid (GABAA) receptors into the MII segment of alpha 7 nicotinic receptor was sufficient to convert a cation-selective channel into an anion-selective channel gated by acetylcholine. A critical mutation was the insertion of an uncharged residue at the amino-terminal end of MII, stressing the importance of protein geometrical constraints on ion selectivity.
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