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  • Title: An immunohistochemical and ultrastructural study of case of small-cell neuroendocrine carcinoma in the ampullary region of the duodenum.
    Author: Sarker AB, Hoshida Y, Akagi S, Hayashi K, Murakami I, Jeon HJ, Takahashi K, Akagi T.
    Journal: Acta Pathol Jpn; 1992 Jul; 42(7):529-35. PubMed ID: 1384272.
    Abstract:
    One case of small-cell neuroendocrine carcinoma in the ampullary region of the duodenum is reported. The histological appearance of the tumor was identical to pulmonary small-cell carcinoma. Neuroendocrine differentiation was demonstrated immunohistochemically by positive immunoreaction for neuron specific enolase, Leu-7 and chromogranin, and ultrastructurally by the presence of scanty dense-core neurosecretory type granules. Small-cell neuroendocrine carcinoma in the ampulla of Vater is extremely rare. To our knowledge, this is the sixth reported case.
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