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  • Title: [Modulation of membrane activity of an enzyme in reversed micelle system with a change of media pH (using alkaline phosphatase as an example)].
    Author: Nametkin SN, LDadaian AK, Kabanov AV, Levashov AV.
    Journal: Bioorg Khim; 1992 Jun; 18(6):777-83. PubMed ID: 1384508.
    Abstract:
    Regulation of the membrane active properties of alkaline phosphatase from calf intestinal mucosa in reversed micelles of Aerosol OT (AOT) in octane was studied. The dependence of the catalytic activity on the surfactant concentration at the constant hydration degree, which characterises the membrane activity of enzymes, is modulated through pH variation. The variation may cause conformational changes of the protein molecule, resulting in exposition of anchor groups which provide the interaction of the enzyme with the micellar matrix.
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