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  • Title: Purification of an active receptor for acidic and basic fibroblast growth factor from bovine retina.
    Author: Torriglia A, Blanquet PR.
    Journal: Biochim Biophys Acta; 1992 Oct 27; 1137(2):215-24. PubMed ID: 1384713.
    Abstract:
    Acidic and basic fibroblast growth factors (FGFs) influence cell division and differentiation in retina cells. Their effects are thought to be mainly mediated through stimulation of a specific membrane receptor and subsequent generation of an intracellular signal pathway. In this study, we purified a FGF receptor of 130 kDa from bovine neural retina using wheat germ agglutinin affinity chromatography followed by FGF-affinity chromatography. The isolated receptor showed ligand binding activity with dissociation constants of 0.8 nM and 2 nM for aFGF and bFGF, respectively. Furthermore, binding of aFGF and bFGF to purified receptor resulted in self-phosphorylation, demonstrating that the isolated receptor had an unaltered intrinsic kinase activity.
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