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  • Title: Streptokinase-producing streptococci grown in human plasma acquire unregulated cell-associated plasmin activity.
    Author: Lottenberg R, DesJardin LE, Wang H, Boyle MD.
    Journal: J Infect Dis; 1992 Aug; 166(2):436-40. PubMed ID: 1386099.
    Abstract:
    Group A streptococci grown in the presence of human plasma generated plasmin from plasminogen and captured the functional enzyme to a specific cell-surface receptor. Bacteria-bound plasmin was not regulated by alpha 2-antiplasmin present in the medium. The ability of the bacteria to acquire cell-associated plasmin activity was dependent on both the presence of plasminogen in the culture medium and the production of a bacterial plasminogen activator, streptokinase. The ability of group A streptococci to produce a plasminogen activator and capture resulting plasmin in an unregulatable form could provide the organism with a mechanism for invasion of normal tissue barriers.
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