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  • Title: Improved heart failure protection by FK664, a novel positive inotropic agent, in dog heart-lung preparations.
    Author: Sudo Y, Takai M, Esumi K.
    Journal: Life Sci; 1992; 51(6):PL41-6. PubMed ID: 1386131.
    Abstract:
    The effects of FK664, a novel positive inotropic agent, and enoximone on pentobarbital-induced heart failure were compared in dog heart-lung preparations. Both FK664 and enoximone improved the cardiac function curve in a dose-dependent manner and restored it to the control level at drug concentrations of 1 microgram/ml and 10 micrograms/ml, respectively. Therefore, the cardiotonic potency of FK664 appears to be 10 times that of enoximone. These agents were almost equal in force-rate separation of cardiac effect. Neither of the agents produced arrhythmia at any dose tested. These results suggest that FK664 may be a potent cardiotonic agent for the treatment of heart failure.
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