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  • Title: Antigenic properties of purified fractions from Ascaris lumbricoides var. Suum on naturally sensitized guinea-pig.
    Author: BERALDO WT, da SILVA W, PUDLES J.
    Journal: Br J Pharmacol Chemother; 1961 Oct; 17(2):236-44. PubMed ID: 13867432.
    Abstract:
    Purified extract of Ascaris injected intravenously into guinea-pigs produced a reaction very similar to the anaphylactic reaction. As shown by the ratio of deaths to survivals the toxic fraction contained in Ascaris extract was purified 3 to 4 times. After intravenous injection animals presented both anaphylaxis-like shock and mast cell damage similar to that observed in anaphylaxis. Perfusion of the lungs with Ascaris fractions released histamine. Isolated guinea-pig ileum when in contact with Ascaris fractions showed a response followed by desensitization. Heating the ileum to 45 degrees C or previous desensitization to anaphylatoxin excluded the participation of the latter in this contraction. In vitro, sensitization from one guinea-pig could be transferred to another, using spleen extract or a 50% ammonium sulphate precipitate obtained from the spleen extract. On the basis of these results it is concluded that guinea-pigs are naturally sensitized to antigen or antigens present in Ascaris lumbricoides.
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