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  • Title: [Transport of Ca2+ in the sarcoplasmic reticulum of skeletal muscles in hyperthermia].
    Author: Avetisova NL, Fedorov AN, Seferova RI.
    Journal: Ukr Biokhim Zh (1978); 1992; 64(1):93-7. PubMed ID: 1387748.
    Abstract:
    Study of functional changes in sarcoplasmic reticulum membranes of the rat skeletal muscles shows that mild hyperthermia is accompanied by the activation of Ca-transporting system function (the increase in accumulation of Ca ions and the rise of Ca(2+)-ATPase activity are observed), a passive release of this ion being unchanged. The revealed changes are regarded as reaction induced by the body temperature increase. The effectiveness of the SR Ca-pump decreases sharply under heat stroke, but the increase of Ca2+ release from SR vesicles is observed. This is considered to be one of possible factors, causing disorder of electromechanical coupling and the disturbance of the skeletal muscle contractility.
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