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  • Title: In vitro effects of Etodolac and acetylsalicylic acid on human chondrocyte metabolism.
    Author: Henrotin Y, Bassleer C, Franchimont P.
    Journal: Agents Actions; 1992 Jul; 36(3-4):317-23. PubMed ID: 1388320.
    Abstract:
    The effects of two nonsteroidal anti-inflammatory drugs (NSAIDs), Etodolac (ETO) and acetylsalicylic acid (ASA), used at pharmacological concentrations, were tested on several metabolic parameters of human chondrocytes cultivated in three-dimensional culture. The results indicated that proteoglycan synthesis was significantly decreased by ASA treatment, whereas Etodolac did not affect this parameter. Neither ASA nor Etodolac modified type-II collagen production. Both NSAIDs were potent inhibitors of PGE2 production, but Etodolac was more efficient at equimolar concentrations. In contrast, collagenolytic activity was unaffected by Etodolac.
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