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  • Title: Effects of alpha methyltyrosine and parachlorophenylalanine on open field behavior in rats given tranylcypromine stereoisomers and lithium carbonate.
    Author: Smith DF, Shimizu M.
    Journal: Pharmacol Biochem Behav; 1976 Nov; 5(5):515-8. PubMed ID: 138857.
    Abstract:
    Parachlorophenylalanine (PCPA) and alpha methyltyrosine (AMT) were used to study the roles of serotonin and catecholamines in hyperactivity produced by the stereoisomers of Tranylcypromine (d-Tc and 1-Tc) in male Wistar rats fed a normal diet (control groups) or a diet containing lithium carbonate (lithium groups). Components of locomotor activity were measured in an open field. Lithium decreased ambulation. d-Tc increased ambulation and caused jerky side-to-side movements. PCPA and AMT prevented the effects of d-Tc on ambulation while only PCPA prevented the effects of d-Tc on movement. 1-Tc increased ambulation. The effects of 1-Tc on ambulation were potentiated by PCPA and prevented by AMT. Rearing was increased by 1-Tc and d-Tc in rats given lithium. PCPA and AMT prevented the effects of 1-Tc and d-Tc on rearing in lithium groups. The findings suggest that the roles of serotoninergic and catecholaminergic mechanisms differ for components of open field behavior in control rats and rats given lithium.
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