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  • Title: Synthesis and pharmacological evaluation of 2,3-dialkylindoles, "in vitro" inhibitors of thrombin-induced platelet aggregation.
    Author: Arcari M, Aveta R, Brandt A, Cecchetelli L, Corsi GB, Solinas F.
    Journal: Farmaco; 1992 Apr; 47(4):405-25. PubMed ID: 1388590.
    Abstract:
    A series of 2,3-dialkylindoles (1-5) have been prepared and tested as antithrombotic agents. The whole class showed in vitro interesting activity in the inhibition of thrombin-induced aggregation. Among these compounds some ones showed activity comparable to standards also in the inhibition of collagen-induced aggregation. Owing to a very fast metabolic degradation through a beta-oxidative mechanism, a drastic decrease of activity in several tests ex vivo or in vivo was observed.
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