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  • Title: Duration of retrograde amnesia induced by tetrodotoxin inactivation of the parabrachial nuclei is inversely related to the intensity of footshock in rat's passive avoidance response.
    Author: Bucherelli C, Tassoni G.
    Journal: Behav Brain Res; 1992 Aug 10; 49(2):175-80. PubMed ID: 1388811.
    Abstract:
    Previous work has demonstrated that in rats post-trial bilateral functional blockade of the parabrachial nuclei by local injection of tetrodotoxin (10 ng in 1 microliter) partially disrupts retention of an overtrained passive avoidance response. The time-course of functional blockade disrupting effects on passive avoidance response has been studied by altering both the acquisition-tetrodotoxin injection interval and footshock intensity as independent variables. When week footshocks (0.8 mA) were delivered, functional ablation of the parabrachial nuclei was still effective when induced up to 8 days after acquisition training. On the other hand, when rats were shocked with the stronger stimuli (1.2 mA), 2 days after acquisition functional ablation was no longer effective. The results are discussed in terms of unconditioned stimulus (US) intensity and engram consolidation.
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