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  • Title: Old microbes with new faces: molecular biology and the design of new vaccines.
    Author: Connell N, Stover CK, Jacobs WR.
    Journal: Curr Opin Immunol; 1992 Aug; 4(4):442-8. PubMed ID: 1388846.
    Abstract:
    Rational approaches to the design of live attenuated bacterial and viral recombinant vaccine strains are leading to the manipulation of old vaccines and the generation of new ones. The two basic problems to be solved are attenuation of pathogenic strains, and the stable expression of foreign antigens.
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